Paul E Brennan Selected Research

KDOAM-25

3/2017

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

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Paul E Brennan Research Topics

Disease

11	Neoplasms (Cancer) 12/2019 - 01/2009
3	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017 - 04/2013
2	Disease Progression 01/2022 - 03/2016
2	Inflammation (Inflammations) 01/2021 - 10/2019
2	Leukemia 12/2018 - 12/2015
1	Schizophrenia (Dementia Praecox) 01/2022
1	Renal Insufficiency (Renal Failure) 01/2022
1	Osteoarthritis 01/2022
1	Primary Hyperoxaluria (Oxaluria, Primary) 01/2022
1	Galactosemias (Galactosemia) 01/2021
1	Friedreich Ataxia (Friedreich's Ataxia) 12/2020
1	Chordoma 10/2020
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/2019
1	Neoplasm Metastasis (Metastasis) 10/2019
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Diffuse Intrinsic Pontine Glioma 01/2019
1	Multiple Myeloma 03/2017
1	Mental Disorders (Mental Disorder) 01/2017
1	Stomach Neoplasms (Stomach Cancer) 07/2016
1	Cardiomyopathies (Cardiomyopathy) 01/2016
1	Genetic Translocation (Chromosomal Translocation) 12/2015
1	Ankylosing Spondylitis 08/2015
1	Psoriatic Arthritis 08/2015
1	Autoimmune Diseases (Autoimmune Disease) 08/2015
1	Urinary Incontinence 05/2011

Drug/Important Bio-Agent (IBA)

3	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2016
3	Lysine (L-Lysine)FDA Link 10/2020 - 12/2018
2	Histones (Histone)IBA 10/2020 - 01/2019
2	Transcription Factors (Transcription Factor)IBA 10/2020 - 01/2019
2	Histone DemethylasesIBA 01/2017 - 01/2017
2	Pharmaceutical PreparationsIBA 01/2017 - 01/2017
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2016 - 12/2015
1	Collagen Type II (Type II Collagen)IBA 01/2022
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2022
1	Protein Isoforms (Isoforms)IBA 01/2022
1	glyoxylic acid (glyoxylate)IBA 01/2022
1	Calcium OxalateIBA 01/2022
1	Peptides (Polypeptides)IBA 01/2022
1	Proteoglycans (Proteoglycan)IBA 01/2022
1	Contrast MediaIBA 01/2022
1	EnzymesIBA 01/2022
1	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 01/2022
1	InflammasomesIBA 01/2021
1	galactose-1-phosphateIBA 01/2021
1	GalactokinaseIBA 01/2021
1	Histone MethyltransferasesIBA 12/2020
1	FrataxinIBA 12/2020
1	Brachyury protein (Brachyury)IBA 10/2020
1	Small Interfering RNA (siRNA)IBA 10/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2019
1	dipinacoline glutamateIBA 01/2019
1	Bromodomain Containing ProteinsIBA 01/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2019
1	Carrier Proteins (Binding Protein)IBA 12/2018
1	KDOAM-25IBA 03/2017
1	ChromatinIBA 01/2017
1	(+)-JQ1 compoundIBA 07/2016
1	IsoxazolesIBA 07/2016
1	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 03/2016
1	AsparagineIBA 03/2016
1	Phosphotransferases (Kinase)IBA 01/2016
1	I-CBP112IBA 12/2015
1	Histone Acetyltransferases (Histone Acetyltransferase)IBA 12/2015
1	Interleukin-17 (Interleukin 17)IBA 08/2015
1	Monoclonal AntibodiesIBA 08/2015
1	Interleukin-23 (Interleukin 23)IBA 08/2015
1	Acetates (Acetic Acid Esters)FDA Link 04/2013
1	Phenol (Carbolic Acid)FDA Link 04/2013
1	PF 3246799IBA 05/2011
1	AzepinesIBA 05/2011
1	5-HT2C Serotonin ReceptorIBA 05/2011
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2009
1	Sirolimus (Rapamycin)FDA Link 01/2009

Therapy/Procedure

4	Therapeutics 01/2021 - 12/2015
1	Drug Therapy (Chemotherapy) 07/2016